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J Natl Cancer Linst 6(100(3)):184-98, 2008
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Our data also suggest that liver might be the major site responsible for the glucose-lowering effect and insulinotropic action of T3
In recent years, advances in cryo-electron microscopy (cryo-EM) have enabled structural determination of a large number of class B1 GPCRs bound to their endogenous agonists, and coupled to G s , including that of the GLP-1R, which confirm engagement of these peptides with both the ECD and the TMD 10,11,12,13,14,15,16,17,18,19,20,21
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