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For weight management, NICE technology appraisals specify eligibility criteria including minimum BMI thresholds and require initiation within specialist weight management services
But if you are sensitive to side effects, currently in the dose-escalation phase, or already experiencing tirzepatide fatigue or GI symptoms, the extra residual drug could amplify those effects temporarily
106(2): p
These doses are approximately 5.5 and 33 times, respectively, the maximum recommended human dose (MRHD) of 70 mg/day given to adults, on a mg/m2 body surface area basis
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