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Compared with the rats treated with APAP alone, rhein treated animals demonstrated significant reduction of the biochemical indicators of liver injury, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea nitrogen (UREA), creatinine (CREA), nitric oxide (NO), and malondialdehyde (MDA)

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GLP-1R V229A displayed a tendency for increased exendin-4-induced cAMP AUC, with kinetic responses that appeared delayed but reached significantly higher maximal cAMP peak levels (Figure 8A, B)

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