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Glutathione and cofactors such as selenium help to neutralize and prevent an excess accumulation of hydrogen peroxide in the cell while maintaining an immune benefit.5 Selenium has also been shown to increase lymphocyte proliferation, the activity of helper T cells, cytotoxic T cells and natural killer cells

The capacity for GSH synthesis is insufficient to maintain GSH concentrations when tissues are exposed to certain drugs or their metabolites (e.g., acetaminophen), redox cycling compounds (e.g., menadione), peroxides (e.g., tertbutyl hydroperoxide), X-rays, or ultraviolet radiation