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Activation of initiators like caspase-9 and caspase 8 in the intrinsic or extrinsic pathways, respectively, promotes the activation of executioner caspases and pro-apoptotic pathways causing DNA injury and apoptosis (Calopa et al
BPC-157 acts locally on angiogenesis and collagen synthesis for tissue repair
doi: 10.1007/s12032-024-02454-x 82
Nanomedicine platforms can be designed to selectively target MDSCs based on their surface receptor expression or metabolic vulnerabilities, thereby reducing systemic immunosuppression while preserving beneficial myeloid populations (32, 33)
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