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The tumor-suppressor p53 plays a pivotal role in cellular responses to various stressors
Oral penetration will be higher in T2D, as diabetes care is principally delivered by primary care physicians who will face lower prescribing barriers with oral GLP-1s
p53 transcriptionally activates the expression of GLS2 (Jennis et al., 2016) and SAT1 (Ou et al., 2016) (a polyamine catabolic enzyme) and transcriptionally represses SLC7A11 (Jiang et al., 2015)
Omega-3 fatty acids reduce the inflammation that can accompany rapid weight loss
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