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Several attempts were undertaken to circumvent this, such as the formulation of a GLP-1 tablet for buccal administration, which was found to improve glycemia in type 2 diabetes ( in vitro studies formed the basis for the hypothesis that DPP-4 inhibition may be a potential novel therapeutic agent to stabilize endogenously released GLP-1
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As of early 2026, there are three published human studies on BPC-157
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