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The following principles reflect general best practice for handling lyophilised injectables in such environments
Yet, caution: what supplements should be avoided with rheumatoid arthritis
Excipient studies on lyophilized rhGH show that sugar and polyol stabilizers (mannitol, sucrose, trehalose) protect the protein's secondary structure and limit aggregation in the dry state by satisfying water-binding sites and stabilizing the amorphous matrix around the protein (Costantino et al., 1998)
Epithalon is selected only when the clinical picture supports it
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