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Therefore, thinning of EAT in HFrEF might reflect underlying increased energy demands of the heart, leading to depletion of the surrounding epicardial fat pad
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After 16 weeks, the group that received semaglutide plus metformin experienced greater weight loss than metformin alone, improved insulin resistance and metabolic markers, better hormonal outcomes (including testosterone), higher rates of menstrual cycle recovery, and higher natural pregnancy rates during followups
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