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TB-500s foundational research application is the study of actin cytoskeletal dynamics through G-actin sequestration modulation and with studies examining how TB-500 influences the ratio of monomeric G-actin to filamentous F-actin in cells, how actin polymerisation dynamics are regulated by Thymosin Beta-4 domain sequestration activity, and how modulating the available G-actin pool through TB-500 influences the actin-dependent cellular processes of migration, division, and morphological organisation
The overall quality of evidence for this outcome was low due to serious imprecision (low number of trials and participants)
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