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A While dietary restriction and exercise were shown to be useful methods for weight loss, the authors concluded that exercise activity alone has only a minor influence on body weight reduction

These studies were soon followed by a number of phase 2 and phase 3 clinical trials with several different DPP-4 inhibitors, all essentially showing that DPP-4 inhibition was a safe and well-tolerated means of improving glycaemic control in patients with T2DM

Understanding Semaglutide: the Science Behind Weight Loss Within months, Sarah saw dramatic weight loss, ultimately losing over 50 pounds