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The glucagon receptor component adds metabolic effects beyond appetite suppression, including enhanced fat oxidation and energy expenditure
Antidiabetic drug metformin ameliorates depressive-like behavior in mice with chronic restraint stress via activation of AMP-activated protein kinase
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[67] studied a cohort of over 400,000 T2DM patients above the age of 65 and found that DPP-4i were associated with a 21% decrease in the risk of MACEs (including myocardial infarction and ischemic stroke) with a 46% overall decrease in risk of all-cause mortality
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