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In hyperuricemic/gouty arthritis rat models, SLN-encapsulated [6]-shogaol exhibited superior efficacy compared to the free drug, marked by greater reductions in serum uric acid, IL-1, and TNF- levels
Moreover, findings from animal studies demonstrate that the administration of ibuprofen can lead to increased markers of oxidative stress, which, in turn, may correlate with lowered glutathione levels
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