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In AD, the brain shows hallmark features of amyloid beta (A) plaque accumulation and neurofibrillary tangles formed by hyperphosphorylated tau protein [2], although prior to diagnosis, a series of neuropathological changes and cognitive decline occur [3]
Front Pharmacol (2016) 7:385
Comorbidities are a factor The patients, all in their 50s and 60s, were prescribed these drugs in the first place because they have diabetes or obesity, as well as other cardiovascular comorbidities, which can by themselves cause diabetic retinopathy, blurring or other vision issues
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