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Additionally, when the body is exposed to high oxidative stress, malnutrition, or an increase in toxic load from environmental contaminants, the need for glutathione increases
Potential masking of underlying hepatic or systemic disease Delayed diagnosis due to symptom suppression Medical supervision is essential to ensure appropriate patient selection, correct dosing, and timely identification of adverse reactions
Yet, the efficiency of such interventions is, in many cases, limited, and additional, second-line treatments are frequently implemented, that mainly involve the use of metformin, as insulin-sensitizer, with variable efficacy in terms of improvement of reproductive and metabolic alterations
As a result, altered intracellular glutathione homeostasis has been widely used as an indicator of oxidative stress
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