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This effect was seen in mild to moderate stages of the disease
Biochemical and biophysical research communications 1992;188(1):102-107
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These combinations are not necessarily off-limits, but they require close monitoring and likely dose reductions in the existing diabetes medication
"Prior weight-loss intervention" does not mean "patient tried to eat less." Acceptable documentation includes: Prescription records showing 90+ days of orlistat, phentermine-topiramate, or naltrexone-bupropion Enrollment records in a structured weight-loss program (e.g., Weight Watchers, Noom, hospital-based program) with attendance logs Bariatric counseling visit notes from a registered dietitian or behavioral health provider, minimum of four visits over 90 days Self-directed diet and exercise, even if documented in provider notes, does not satisfy step therapy in most eviCore reviews
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