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On chromosome 1, we observed a significant number of associated variants near the TMCO1 gene, which has been implicated in various disorders, including POAG, craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 25
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Py230 cells (provided by Nicholas Webster and Lesley Ellies, University of California San Diego) were maintained in F12K Nutrient Mixture (Corning 10-025-CV) supplemented with 5% Fetal Clone II (Cytiva SH30066.03), 50 g/mL gentamycin (Sigma-Aldrich G1397), 2.5 g/mL amphotericin B (Sigma-Aldrich A2942), and 1 L/mL MITO+ Serum Extender (Corning 355006) at 37 C and 5% CO 2
The first is the operation
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