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Diarrhea is a side effect of GLP-1 receptor activation in the gut, but it is not directly related to weight loss effectiveness
Participants who completed a 36-week lead-in period showed a mean weight reduction of 20.9%, with those continuing tirzepatide reaching an overall reduction of 25.3% from baseline to week 88
47, 390 (2023), Abstract Mitochondrial Dysfunction Involved in the Cytotoxicity of Tramadol in Human Endometrial Carcinoma Cells: L.C
This study represents one of the largest metabolomic studies of a clinical cohort
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