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Women of childbearing potential should be advised to use non-oral contraception or add a backup method for 4 weeks after initiation and after each dose escalation due to tirzepatide's effect on gastric emptying

Long-term carcinogenicity data in rodents is limited

Clinical Trial Details (Pilot Study) A pilot Phase I study demonstrated MT-II's tanning activity in humans given only five low doses every other day by subcutaneous injection

Important safety information includes a boxed warning for thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) and warnings for pancreatitis, gallbladder disease, acute kidney injury, and hypoglycemia risk when used with insulin or sulfonylureas