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Notably, researchers have documented that the peptide appears to upregulate NO production when it is deficient and downregulate it when excessive, suggesting a modulatory rather than simply stimulatory relationship
In addition, Orai1, a Ca 2+ channel, has emerged as a key regulator of reactive astrocytes by controlling the synthesis and release of a broad range of proinflammatory mediators 113
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Neuropsychopharmacology 22 : 466472
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