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Brown PM, Drossman DA, Wood AJ, Cline GA, Frazier KS, Jackson JI, Bronner J, Freiman J, Zambrowicz B, Sands A, Gershon MD: The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome
Mitophagy inhibits macrophage activation and thus immune defense, resulting in decreased pathogen clearance and infection, while inhibition of mitophagy in macrophages can promote macrophage activation and thus inhibit infection
Additionally, this inflammatory dialogue is amplified by increased levels of FFAs (i.e
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J Neuroendocrinol 30:e12502
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