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GLP-1 receptor agonists cause fatigue primarily through indirect mechanisms including substantial caloric restriction from appetite suppression, gastrointestinal side effects leading to dehydration and nutritional deficits, and metabolic adaptation during weight loss
If you're allergic to any ingredients, are pregnant or nursing, or have liver or kidney issues, these injections may not be suitable for you
Food and Drug Administration (2024) 2
That said, however, in most people I usually see a noticeable (although not always lasting) improvement after 2-3 shots
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