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Another mechanism is that GLP-1 may reduce RGC loss indirectly by preventing Mller cell gliosis

At high doses (over 3 g), nausea, stomach cramps, diarrhea, and a "fishy body odor" (trimethylamine accumulation) can occur

Yang T, Li S, Xu H, Walsh DM, Selkoe DJ (2017) Large soluble oligomers of amyloid -protein from Alzheimer brain are far less neuroactive than the smaller oligomers to which they dissociate