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Orlistat caused malabsorption of fat-soluble vitamins including vitamin D, which matters for testosterone synthesis
Because of this noxious effect, it was taken off the market.48 Pioglitazone is metabolized by the CYP2C8l and CYP3A4 system.49 There are no pharmacodynamic studies evaluating the effects of this drug in patients with CLD, and it may induce increase of body weight
GLP-3 is the successor compound from the same manufacturer (Novo Nordisk) and produces larger absolute weight loss at maximum dose in cross-trial comparison
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