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The enzymatic activity of GLS-1 was evaluated by measuring the intracellular glutamate concentration in the presence of 0.01 M to 100 M of CB-839

However, calorie deficit, active lifestyle, behavior therapy, and drug therapy reduce inflammatory markers and regulate insulin levels commonly associated with cancer progression [17, 18]

However, no cognitive improvement was identified, which probably reflects the limited statistical power and short treatment period of the trial to identify meaningful differences