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Our earlier research showed that a natural protective response, mediated by the vagus nerve, releases GLP-1 from the gut, and this dramatically reduces the infarct size, Svetlana Mastitskaya, MSci, PhD, senior lecturer in cardiovascular regenerative medicine at Bristol Medical School: Translational Health Sciences (THS) at the University of Bristol, United Kingdom, and lead author of this study, told Medical News Today
38,238,243 Besides, the oscillation activation of SIRT1 also regulates the circadian dynamics via deacetylation of the core clock repressor PER2 K680 and mixed-lineage leukemia 1 (MLL1), thereby controlling rhythmic chromatin property and the activity of BMAL1: CLOCK complex
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