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In terms of helping with weight loss, semaglutide affects the brain signals that control appetite and food intake, making a person feel less hungry and more satisfied with smaller portions, contributing to weight loss
Common side effects like nausea and vomiting are usually short-lived and manageable
Another unknown is what happens when large numbers of people use these drugs in the real world, outside the controlled environment of a clinical trial
The biological mechanism is well understood, even though the exact trigger varies from person to person
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