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Novo Nordisk's PIONEER TEENS Trial: What Happened On April 23, 2026, Novo Nordisk announced positive topline results from PIONEER TEENS , a Phase 3a clinical trial that is historic in its scope: it marks the first time an oral GLP-1 receptor agonist (GLP-1 RA) has ever been evaluated in a pediatric population

The most frequently reported adverse events involve gastrointestinal symptoms like nausea and constipation, which typically resolve within weeks