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Nat Rev Dis Primers (2017): Vitamin B12 is essential for normal nervous system function via its role in myelin synthesis and for circulatory system function through its role in red blood cell maturation in the bone marrow
Surgical procedures or conditions that affect the gut, such as gastric bypass surgery or celiac disease, can prevent intrinsic factors from binding to B12 and prevent the body from breaking it down before absorbing the vitamin
These injections have no risks and are safe to administer
What is supported in animal models Increased lipolysis, increased fat oxidation, decreased lipogenesis, no apparent effect on plasma glucose or insulin sensitivity, and signal that intact beta-3 adrenergic receptor activity matters for the fat-loss effect
