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2022 Oct 23;27(21):7167
In addition to its role in cellular defense, the Nrf2 pathway has been implicated in numerous physiological and pathophysiological processes, including aging, neurodegeneration, cancer, and metabolic disorders [77]
Since GSH is exported rapidly from liver cells and much of the export is broken down into the constituent amino acids that are then reimported into liver cells, it was necessary to include the blood compartment in our model
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