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As mentioned earlier, the most important effect of incretins is to stimulate the production and secretion of insulin by the pancreas, and clinical studies show that the activation of this process, whether by stimulation of GLP-1 by semaglutide alone or simultaneous stimulation of GLP-1/GIP by tirzepatide, is associated with better glycemic control in type 2 diabetics
Most patients notice significant weight loss during the first month when combined with lifestyle changes
The microbiome helps respond to dietary lipid changes by modulating intestinal epithelial digestive and absorptive processes in mice and zebrafish [59, 60]
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