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For example, esculetin (6,7-dihydroxycoumarin), a bioactive constituent of Fraxinus rhynchophylla Hance, can prevent and treat the occurrence of NAFLD in diabetes by downregulating the liver lipid synthesis genes ( Fasn , Dgat2 , and Plpp2 ) and reducing lipid peroxidation [268]
In major clinical trials, such as the landmark STEP 1 trial published in the New England Journal of Medicine , a once-weekly injection of semaglutide 2.4 mg resulted in an average body weight reduction of roughly 14.9% over 68 weeks
This evaluation should include a detailed history of the cholecystectomy, including the indication for surgery, any complications, and current digestive function
The Bottom Line The DiMarchi/Tschp paper does not invalidate GLP-1 drugs
