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Bispecific molecules are more often designed to target antigens expressed on the same cell or cells within the same environment but our data also demonstrates the feasibility of achieving dual pharmacology when targeting molecules in very different compartments: a soluble serum protein (PCSK9) and a GPCR predominately expressed in pancreatic -cells (GLP-1R)

This happens because it can increase acid production in the stomach, leading to a burning feeling in the chest or throat

The rise of plasma TMAO was on average three-fold compared with white meat and non-meat diets [70]

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