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Each enzyme family is characterized by a distinct 3D structure, amino acid sequence, and with regard to the metal-binding cofactor(s) used to support its structural stability and catalytic activity (Case 2017): either manganese (MnSOD), nickel (NiSOD), or both copper and zinc (Miller 2012)

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Topical/cosmetic GHK-Cu Human studies on GHK-Cu have primarily focused on the topical route of administration

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