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Lipid metabolism reprogramming and trastuzumab resistance in breast cancer cell lines overexpressing the ERBB2 membrane receptor

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L-Carnitine is essential for the energy metabolism , including body fat , as it carryes long-chain fatty acids to the mitochondria, thus allowing the fat burn

In a follow-up study, OJP down-regulated the expression of PI3K/p85, AKT, InsR, insulin receptor submatter-1 (IRS-1) and glucose transporter type 4 (Glut-4), down-regulated the expression of glycogen synthase kinase 3 (GSK-3), and played a hypoglycemic effect through InsR/InsR-1/PI3K/Akt/GSK-3/Glut-4 signaling pathway