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Am J Physiol (1995) 269(6 Pt 2):R131420

The precise physiological and molecular consequences of how a loss of PAM affects GLP-1 levels and signaling is likely to be complex since so many hypothalamic and peripherally secreted peptides involved in the regulation of energy homeostasis are amidated [52] and a central action of PAM in GLP-1 resistance can be ruled out [53]

The GLP-1 component of Retatrutide provides the established benefits of incretin therapy, while the addition of GIP receptor activation enhances insulin secretion and glucose uptake in peripheral tissues