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140 For instance, decreased expression of the organic cation transporter OCT2 (SLC22A2) confers resistance to platinum-based drugs in pancreatic and ovarian cancers by reducing cellular drug accumulation
The use of probiotics like Lactobacillus and Bifidobacterium to improve gut microbiota and ameliorate cognitive deficits in AD models further expands the systemic promise of these interventions (Pan et al., 2022
For example, Oeseberg showed that dipeptidyl-peptidase 4 (DPP-4) inhibition significantly reduced vascular senescence in a diabetic rat model
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