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9 Challenges and limitations to compliance with GLP-1 RA therapy While GLP-1 RA therapies are highly effective for glycemic control and weight loss, real-world data indicate that many patients either discontinue or struggle to adhere to these treatments
Some patients may prefer to switch from the pill to the injection if they want a more convenient, once-weekly treatment, while others may prefer to switch from the injection to the pill if they find the injection too difficult to manage
The LEADER trial (liraglutide), SUSTAIN-6 (semaglutide), and EXSCEL (exenatide) studies, which collectively followed thousands of patients for several years, did not report significant increases in fracture rates compared to placebo groups
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