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Proper vascularization is needed to provide the body with cholesterol substrates, oxygen and gonadotropins, all of which are vital to the maintenance of progesterone biosynthesis and luteal cell survival (75)
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Although GLP-1 medications have transformed obesity treatment, there remains a significant need for rigorous data examining how these therapies affect fertility and reproductive function in this population. The RESTORE study is currently evaluating semaglutide treatment in girls and women with PMOS and obesity, with the overarching goal of determining whether weight loss and metabolic improvements can restore ovulation and improve reproductive outcomes
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