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Both scenarios share the same principle: BPC-157 does not stop working
The activated JNK [phospho-c-Jun N-terminal kinase (p-JNK)] combines with its target SH3 domain-binding protein (Sab) on the mitochondrial membrane, leading to a self-sustaining activation circuit of ROS production and JNK activation, which eventually leads to the opening of mitochondrial membrane permeability transition pore (MPT) [61]
These dual-function HDTs highlight the potential for multifunctional therapies that target both bacterial survival and host immunopathology
Knaff, David
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