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These can include pancreatitis, thyroid tumors, gallbladder issues, allergic reactions, and hypoglycemia

This creates a vicious cycle: the oxidative stress further damages the mitochondrial DNA and lipid membranes, which in turn causes even more mitochondrial dysfunction and energy depletion

Disruptions in the intrinsic factor (IF) pathway, including impaired IF production due to autoimmune conditions (pernicious anemia), damage to the ileum from diseases like Crohns or celiac disease, or surgical resection of the ileum, can severely impair B12 absorption

If you are pregnant or want to become pregnant, you should never use Accutane