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Growing evidence suggests that CRC cells exploit specific metabolic adaptation mechanisms to cope with the microenvironments of distant organs, thereby enhancing their invasiveness and metastatic colonization capacity
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), a key regulator of mitochondrial biogenesis, is upregulated in small cell neuroendocrine PC (SCNC) (Varuzhanyan et al., 2024)
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Traditional diagnostic approaches often depend on clinicians' subjective judgment, which may lead to misdiagnosis or missed cases
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