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A surgeon reported the first clinical case of what is now called SjD in 1888, describing a male patient with painless bilateral swelling of the lacrimal, parotid, and submandibular glands (i.e., the glands that produce tears and saliva)

These studies primarily measured oxygen consumption, which provides an indirect measure of DNPs effects since it can be influenced by various mitochondrial processes beyond the proton gradient

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Healthcare providers considering this medication for their patients should understand that it represents a compounded formulation prepared specifically for individual patients based on the prescribing clinicians determination of patient need