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Description

Topiramate modulates neuronal excitability through multiple mechanisms: it enhances gamma-aminobutyric acid (GABA) activity, blocks voltage-gated sodium channels, and inhibits certain carbonic anhydrase isoenzymes

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In STEP 1 (just under 2,000 participants, 68 weeks) the mean weight loss was minus 14.9%, with an alopecia rate of around 3% versus 0.9% on placebo

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However, edibles can be harder to dose accurately and may have significantly delayed, prolonged effects when taken with Wegovy due to delayed gastric emptying

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Age and body composition matter more than the number alone

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