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In the SURMOUNT-4 trial, tirzepatide achieved weight reductions of up to 22.5% at the highest dose, with some subgroups showing even greater loss compared to semaglutide alone
Hypersensitivity Reactions: Anaphylaxis or angioedema has been reported in clinical trials
In two studies examining the 6-month effects of semaglutide, patients with metabolic dysfunction-associated steatotic liver diseases (MASLD) and showed reduced skeletal muscle steatosis with preservation of muscle mass [86], whereas in patients with MASLD and human immunodeficiency virus, semaglutide led to a 9.3% decrease in psoas muscle volume with no change in muscle fat fraction [87]
The drawback is that if you have morning hunger as part of your routineor if you rely on breakfast to fuel your workoutyou might miss that appetite-suppressing window
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