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Preparation and properties
The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)
(Enko 2016) A 2019 SR and MA of 867 participants with H
It is a synthetic form of B12 that contains a cyanide moleculethough the amount is negligible and considered safe for use in food supplements by European food safety authorities
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