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Despite that UPR helps cells to cope with ER stress, prolonged ER stress induces apoptotic cell death where the accumulation of unfolded protein in ER results in increased expression activating transcription factor 4 (ATF-4) that in turn increases the transcription of the proapoptotic protein, C/EPB-homologous protein-10 (CHOP-10) (Li et al., 2014)
Further preclinical and clinical studies could provide evidence for EGCGs translational potential in TBI management
Glutathione and NAC both act as powerful antioxidants
These authors also concluded that 61 d creatine supplementation did not suppress endogenous synthesis to an extent that would affect plasma Hcy levels in healthy women
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