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Adjust dosing depending on the subjects response and research methodology
Sport restriction: As an unapproved substance, FOXO4-DRI falls under WADAs S0 catch-all and is prohibited for athletes
This underdiagnosis can lead, besides death in 20% when it is not appropriately treated, to Korsakoffs syndrome, a severe dysfunction often following untreated Wernickes encephalopathy, that does not remit even with thiamine treatment and is associated with chronic alcohol abuse and chronic thiamine deficiency (5, 6, 11, 28)
This process is shown in the following animation, as well as in the figure below
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