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Published analyses indicate that on first-submission , only roughly 3035% of GLP-1 requests are approved (implying roughly 6570% denied) ( [3] ) ( [4] )
Less common but more serious risks include pancreatitis, gallbladder problems, and, rarely, kidney issues tied to dehydration from vomiting
All GLP-1 receptor agonists carry a boxed warning for risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), and are contraindicated in patients with personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2
Expanding Indications: Beyond obesity, Zepbound is being explored for cardiovascular risk reduction, heart failure, and even Alzheimers disease management
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