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Sarah Stolte , assistant professor of Internal Medicine and division director of obesity medicine at the University of Kansas Medical Center and advisor to the Kansas Center for Metabolism and Obesity Research COBRE
Final Verdict
The fasting treatment consisted of 2 days with moderate calorie restriction (700800 Kcal/day), 5 days of intense calorie restriction (200 Kcal/day), followed by 3 days with the stepwise reintroduction of a normal diet
Rather, the majority of orally ingested l-carnitine in mice produced a previously unappreciated intermediary metabolite, -butyrobetaine (BB), in a gut microbiotadependent step that occurred at a site anatomically proximal to, and at a rate 1,000-fold higher than the rate of the formation of TMA (26)
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